Iodotyrosine deiodinase
Iodotyrosine deiodinase also known as iodotyrosine dehalogenase 1 is an enzyme that in humans is encoded by the IYD gene.[1][2][3]
Function
Iodotyrosine deiodinase facilitates iodide salvage in thyroid by catalyzing deiodination of mono- and diiodotyrosine, the halogenated byproducts of thyroid hormone production.[2]
Clinical significance
Mutations in the IYD gene are associated with hypothyroidism.[4]
See also
References
- ^ Gnidehou S, Caillou B, Talbot M, Ohayon R, Kaniewski J, Noël-Hudson MS, Morand S, Agnangji D, Sezan A, Courtin F, Virion A, Dupuy C (October 2004). "Iodotyrosine dehalogenase 1 (DEHAL1) is a transmembrane protein involved in the recycling of iodide close to the thyroglobulin iodination site". FASEB J. 18 (13): 1574–6. doi:10.1096/fj.04-2023fje. PMID 15289438.
- ^ a b Friedman JE, Watson JA, Lam DW, Rokita SE (February 2006). "Iodotyrosine deiodinase is the first mammalian member of the NADH oxidase/flavin reductase superfamily". J. Biol. Chem. 281 (5): 2812–9. doi:10.1074/jbc.M510365200. PMID 16316988.
- ^ "Entrez Gene: IYD Iodotyrosine deiodinase". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=389434.
- ^ Moreno JC, Klootwijk W, van Toor H, Pinto G, D'Alessandro M, Lèger A, Goudie D, Polak M, Grüters A, Visser TJ (April 2008). "Mutations in the iodotyrosine deiodinase gene and hypothyroidism". N. Engl. J. Med. 358 (17): 1811–8. doi:10.1056/NEJMoa0706819. PMID 18434651.
Further reading
- Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6.". Nature 425 (6960): 805–11. doi:10.1038/nature02055. PMID 14574404.
- Moreno JC (2003). "Identification of novel genes involved in congenital hypothyroidism using serial analysis of gene expression.". Horm. Res. 60 Suppl 3: 96–102. doi:10.1159/000074509. PMID 14671405.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Afink G, Kulik W, Overmars H, et al. (2008). "Molecular characterization of iodotyrosine dehalogenase deficiency in patients with hypothyroidism". J. Clin. Endocrinol. Metab. 93 (12): 4894–901. doi:10.1210/jc.2008-0865. PMID 18765512.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
- Gieger C, Geistlinger L, Altmaier E, et al. (2008). Gibson, Greg. ed. "Genetics Meets Metabolomics: A Genome-Wide Association Study of Metabolite Profiles in Human Serum". PLoS Genet. 4 (11): e1000282. doi:10.1371/journal.pgen.1000282. PMC 2581785. PMID 19043545. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2581785.
- Thomas SR, McTamney PM, Adler JM, et al. (2009). "Crystal Structure of Iodotyrosine Deiodinase, a Novel Flavoprotein Responsible for Iodide Salvage in Thyroid Glands". J. Biol. Chem. 284 (29): 19659–67. doi:10.1074/jbc.M109.013458. PMC 2740591. PMID 19436071. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2740591.
- Krause K, Karger S, Gimm O, et al. (2007). "Characterisation of DEHAL1 expression in thyroid pathologies". Eur. J. Endocrinol. 156 (3): 295–301. doi:10.1530/EJE-06-0596. PMID 17322488.
- Gnidehou S, Lacroix L, Sezan A, et al. (2006). "Cloning and characterization of a novel isoform of iodotyrosine dehalogenase 1 (DEHAL1) DEHAL1C from human thyroid: comparisons with DEHAL1 and DEHAL1B". Thyroid 16 (8): 715–24. doi:10.1089/thy.2006.16.715. PMID 16910871.
- Otowa T, Yoshida E, Sugaya N, et al. (2009). "Genome-wide association study of panic disorder in the Japanese population". J. Hum. Genet. 54 (2): 122–6. doi:10.1038/jhg.2008.17. PMID 19165232.
External links
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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